New angiogenesis study results reported from Hiroshima University

Tag : gamma-butyrolactone (gbl)


Angiogenesis

New angiogenesis study results reported from Hiroshima University

July 11th, 2008

According to recent research from Japan, " The aim of this studywas to evaluate the potential role of UFT and its metabolite gamma-butyrolactone (GBL) for inhibition of angiogenesis induced by vascular endothelial growth factor (VEGF) in advanced cervical carcinoma by the determination of serum GBL and VEGF , and by immunohistochemical staining to assess VEGF protein expression, before and after UFT therapy . The subjects were 35 patients with an advanced cervical carcinomaand five healthy volunteers between 2002 and 2003 at HiroshimaUniversity Hospital, under informed consent ."
"The patients received two courses of oral fluoropyrimidine (UFT) therapy at a dose of 600...

Source: Angiogenesis Weekly (2008-07-11)
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