Technically speaking from tranexamic acid on freckles to nonanimal fillers

Tag : tranexamic acid


Charles Fox, Independent Consultant
Skin and Skin Care
Tranexamic acid (TA) on pigmentation: Kondou et al. have publishedresults from a clinical study examining the effects of a tranexamicacid (TA) emulsion applied topically to melasma and freckles.1 Thestudy involved 33 subjects, 25 with melasma and 8 with freckles,who applied the TA emulsion for five to eighteen weeks, after whichtheir skin pigmentation was visually assessed by a dermatologist.
Researchers found that the TA emulsion had improved thepigmentation in 20 subjects with melasma (80%) and 6 subjects (75%)with freckles. No side effect was recognized and thus the TAemulsion was deemed safe. In regard to changes over the course ofthe study, marked improvement was observed within eight weeks formelasma but within 12 weeks for freckles; therefore, improvementwas considered to require at least two months of topicalapplication. The authors concluded the TA emulsion was an effectivecosmeceutical that provided a whitening effect on melasma andfreckles through inhibition of melanin synthesis. It also preventedthe appearance of new pigment spots and freckles.
Trans-retinol and skin: Pudney et al. have published an in vivo confocal Raman studyexamining the delivery of trans-retinol into human skin.2 Deliveryto real living systems such as skin can be difficult to execute andis problematic to confirm and measure. So far, methods for studyingthe delivery of compounds through the skin are mostly ex vivo; thusthey inherently influence the skin and may not translate directlyto an in vivo situation. Raman spectroscopy is unique in itsability to measure biological processes in vivo.
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