Apple Extracts Prevent Aspirin-Induced Damage

Tag : apple polyphenol

NAPLES, Italy —In a recent study published in the British Journal of Nutrition Cambridge University Press researchers speculated that apple polyphenol extract (APE) may betherapeutic in prophylaxis of aspirin-related gastropathy (2008)(DOI: 10.1017/S0007114508988747 ). Rats were treated with APE before 200 mg/kg of oral aspirin. APEdecreased acute and chronic aspirin injury both macroscopically andmicroscopically (approximately 50 percent decrease in lesion score;P<0.05). APE also reduced aspirin-induced mRNA and proteinover-expression of cyclo-oxygenase-2 (COX-2) and heparin-bindingepidermal-growth-factor-like growth factor (HB-EGF); APEpre-treatment counteracted the gastric MDA increase caused byaspirin. APE did not significantly affect gastric acid secretion.