Sirtris Pharmaceuticals Presents at American Chemical Society
[2008-4-2]
Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, announced that it will be presenting at the American Chemical Society annual meeting in New Orleans on Monday, April 7 at 7:00 pm EDT.
Jean Bemis, Sirtris Associate Director of Chemistry, will present an abstract on the identification of novel small molecule activators of SIRT1, the founding member of the sirtuin family of enzymes associated with diseases of aging. Using high throughput mass spectrometry, Sirtris has identified new chemical entity (NCE) activators of SIRT1 that are chemically distinct from, and up to 1000 times more potent in in-vitro studies than resveratrol, the compound shown to reduce glucose and improve insulin sensitivity in preclinical studies.
Sirtris' NCEs have been shown to lower glucose and improve insulin sensitivity in predictive pre-clinical models of Type 2 Diabetes. SIRT1 activators have the potential to be a frontline therapy for Type 2 Diabetes.
Sirtris plans to have one of its NCEs in a Phase 1 human clinical safety trial in the first half of 2008.
Sirtris Pharmaceuticals is a biopharmaceutical company focused on discovering and developing proprietary, orally available, small molecule drugs with the potential to treat diseases associated with aging, including metabolic diseases such as Type 2 Diabetes. Our drug candidates are designed to mimic certain beneficial health effects of calorie restriction, without requiring a change in eating habits, by activation of sirtuins, a recently discovered class of enzymes that the Company believes control the aging process. Sirtris Pharmaceuticals is engaged in human clinical trials for Type 2 Diabetes, and is planning similar trials in cancer, another age-related disease. Sirtris is also engaged in a human clinical trial for MELAS, a mitochondrial disorder. The company's headquarters are in Cambridge, Massachusetts.
Jean Bemis, Sirtris Associate Director of Chemistry, will present an abstract on the identification of novel small molecule activators of SIRT1, the founding member of the sirtuin family of enzymes associated with diseases of aging. Using high throughput mass spectrometry, Sirtris has identified new chemical entity (NCE) activators of SIRT1 that are chemically distinct from, and up to 1000 times more potent in in-vitro studies than resveratrol, the compound shown to reduce glucose and improve insulin sensitivity in preclinical studies.
Sirtris' NCEs have been shown to lower glucose and improve insulin sensitivity in predictive pre-clinical models of Type 2 Diabetes. SIRT1 activators have the potential to be a frontline therapy for Type 2 Diabetes.
Sirtris plans to have one of its NCEs in a Phase 1 human clinical safety trial in the first half of 2008.
Sirtris Pharmaceuticals is a biopharmaceutical company focused on discovering and developing proprietary, orally available, small molecule drugs with the potential to treat diseases associated with aging, including metabolic diseases such as Type 2 Diabetes. Our drug candidates are designed to mimic certain beneficial health effects of calorie restriction, without requiring a change in eating habits, by activation of sirtuins, a recently discovered class of enzymes that the Company believes control the aging process. Sirtris Pharmaceuticals is engaged in human clinical trials for Type 2 Diabetes, and is planning similar trials in cancer, another age-related disease. Sirtris is also engaged in a human clinical trial for MELAS, a mitochondrial disorder. The company's headquarters are in Cambridge, Massachusetts.
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