AnaSpec Offers Custom Synthesis of Hydrocarbon-Stapled Peptides

Tag : Custom Synthesis

Hydrocarbon-stapled peptides are peptides capable of forming stablealpha helical structure as a result of "hydrocarbon stapling."1,2Many biological pathways, such as signal transduction, occurbecause of intracellular protein-protein interactions, whichfrequently are mediated by the a-helix structures of proteins;however, the use of short protein fragments (peptides) leads to aloss of secondary structure, such as alpha helical structure. Shortpeptides are easily degraded by proteolysis and have difficulty inintact cells penetration.1 Verdine's group has shown that theseproblems could be overcome by a chemical modification of analpha-helical peptide they termed hydrocarbon-stapled peptide.1,2The modified hydrocarbon-stapled peptide is helical, relativelyprotease resistant, cell-permeable and binds with increased bindingaffinity to its target. Hydrocarbon stapling may provide a usefulstrategy in researching experimental and therapeutic modulation ofprotein-protein interactions as well as in in vivo pharmacokineticsstudies.
Company Info AnaSpec, Inc. is a leading provider of integratedproteomics solutions to pharmaceutical, biotech, and academicresearch institutions throughout the world. With a vision forinnovation through synergy, AnaSpec focuses on three coretechnologies: peptides, detection reagents (dyes, assay kits, &antibodies), and combinatorial chemistry.
For more information, visit www.anaspec.com
References:
1.. Walensky, LD. et al. Science 305, 1466 (2004). 2..Schafmeister, CE. et al. J. Am. Chem. Soc. 122, 5891 (2002). 3..Qiu, W. et al. Tetrahedron 56, 2577 (2000). 4.. Belokon, Y. N. etal. Tetrahedron: Asymmetry 9, 4249 (1998).
Thanks,
Ping Yang
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